News and Publications

March 2023
Oragenics Announces Positive Results in Several Lantibiotics Compounds Against MRSA and VRE. Read more…

2022
Linnaeus receives funding from the Bill and Melinda Gates Foundation screen novel compounds active against Mycobacteroides using MycoBCP. Read more…

2019
Linnaeus receives funding from the Bill and Melinda Gates Foundation to develop BCP for Mycobacteroides Read more…

2017
Bacterial Cytological Profiling receives Omura Prize for best article of the year from the Journal of Antibiotics.

Sun D, Tsivkovski R, Pogliano J, Tsunemoto H, Nelson K, Rubio-Aparicio D, Lomovskaya O. Intrinsic Antibacterial Activity of Xeruborbactam In Vitro: Assessing Spectrum and Mode of Action. Antimicrob Agents Chemother. 2022 Oct 18;66(10):e0087922. doi: 10.1128/aac.00879-22. Epub 2022 Sep 14. PMID: 36102663; PMCID: PMC9578396.

Blaskovich MAT, Kavanagh AM, Elliott AG, Zhang B, Ramu S, Amado M, Lowe GJ, Hinton AO, Pham DMT, Zuegg J, Beare N, Quach D, Sharp MD, Pogliano J, Rogers AP, Lyras D, Tan L, West NP, Crawford DW, Peterson ML, Callahan M, Thurn M. The antimicrobial potential of cannabidiol. Commun Biol. 2021 Jan 19;4(1):7. doi: 10.1038/s42003-020-01530-y. PMID: 33469147; PMCID: PMC7815910.

Andrews LD, Kane TR, Dozzo P, Haglund CM, Hilderbrandt DJ, Linsell MS, Machajewski T, McEnroe G, Serio AW, Wlasichuk KB, Neau DB, Pakhomova S, Waldrop GL, Sharp M, Pogliano J, Cirz RT, Cohen F. Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase. J Med Chem. 2019 Aug 22;62(16):7489-7505. doi: 10.1021/acs.jmedchem.9b00625. Epub 2019 Aug 9. PMID: 31306011; PMCID: PMC6980355.

Lamsa A, Liu WT, Dorrestein PC, Pogliano K. The Bacillus subtilis cannibalism toxin SDP collapses the proton motive force and induces autolysis. Mol Microbiol. 2012 May;84(3):486-500. doi: 10.1111/j.1365-2958.2012.08038.x. Epub 2012 Apr 2. PMID: 22469514; PMCID: PMC3839633.

Nonejuie P, Burkart M, Pogliano K, Pogliano J. Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16169-74. doi: 10.1073/pnas.1311066110. Epub 2013 Sep 17. PMID: 24046367; PMCID: PMC3791758.

Quach DT, Sakoulas G, Nizet V, Pogliano J, Pogliano K. Bacterial Cytological Profiling (BCP) as a Rapid and Accurate Antimicrobial Susceptibility Testing Method for Staphylococcus aureus. EBioMedicine. 2016 Jan 18;4:95-103. doi: 10.1016/j.ebiom.2016.01.020. PMID: 26981574; PMCID: PMC4776060.

Kumaraswamy M, Lin L, Olson J, Sun CF, Nonejuie P, Corriden R, Döhrmann S, Ali SR, Amaro D, Rohde M, Pogliano J, Sakoulas G, Nizet V. Standard susceptibility testing overlooks potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas maltophilia. J Antimicrob Chemother. 2016 May;71(5):1264-9. doi: 10.1093/jac/dkv487. Epub 2016 Jan 31. PMID: 26832758; PMCID: PMC4830416.

Nonejuie P, Trial RM, Newton GL, Lamsa A, Ranmali Perera V, Aguilar J, Liu WT, Dorrestein PC, Pogliano J, Pogliano K. Application of bacterial cytological profiling to crude natural product extracts reveals the antibacterial arsenal of Bacillus subtilis. J Antibiot (Tokyo). 2016 May;69(5):353-61. doi: 10.1038/ja.2015.116. Epub 2015 Dec 9. PMID: 26648120; PMCID: PMC5367885.