Joe Pogliano

Joe Pogliano is a Professor of Biological Sciences at the University of California San Diego and cofounder of Linnaeus Bioscience Inc. He received B.S. degrees in Chemistry and Honors Biology from the University of Illinois, Champaign. He obtained a Ph.D. from Harvard Medical School where he studied cell division, outer membrane stress responses, antibiotic mechanism of action and protein secretion. As a post doc at the University of California San Diego he studied cytoskeletal proteins involved in plasmid DNA segregation. He joined the UCSD faculty in 2003 where his research has focused on using cell biological tools to study bacterial cell growth, DNA replication, cell division, outer membrane biogenesis, and the mechanisms by which antibiotics target these essential cellular processes. His lab recently discovered the “phage nucleus”, a compartment formed by many bacteriophage that replicate in Pseudomonas. The phage nucleus compartmentalizes phage replication, with phage DNA and enzymes required for replication and transcription localized inside the nucleus while phage structural proteins and metabolic enzymes localize in the cytoplasm. He and Kit Pogliano developed Bacterial Cytological Profiling (BCP) technology that provides a rapid method for screening for antibiotics against multidrug resistant bacteria and understanding their mechanisms of action and founded Linnaeus Bioscience, Inc. to commercialize this technology. He has over 60 publications in the fields of bacterial cell biology and antibiotic mechanism of action.